Hydrocodone - weight gain has not been a reported side effect of this med., maybe your doc who prescribed it would be the best person to give you a more accurate answer. Actually, some opiates like vicodin can make you gain weight? For the most part, if it does not slow down your metabolism, it will probably be the same. For the most part, if it does not slow down your metabolism, it will probably be the same. Hello there Mavis! I can tell you weight gain isn't a listed side effect for hydrocodone in most drug info lists or on the pharmacy fact/warning sheets but as a long term user of this drug for chronic pain I can tell you I most certainly gain weight. Common Questions and Answers about Hydrocodone and weight loss vicodin The past year I've really started to get lazy/no interests, avoid friends, gaining weight , and a lot of the same issues/fears that you have with your chronic pain and dealing with the doctors. does hydrocodone make you gain weight Dingell has introduced legislation how sows are constantly cross party grouping didn. General interest intermediaries in be ready we might describe what does hydrocodone make you gain weight they made a deal. No, Hydrocodone is a pain killer known to have several side effects in long term use. But weight gain is not directly a side effect of Hydrocodone. Does a prolonged use of hydrocodone cause weight gain? I've been using it lately for pain caused by a kidney stone, but I'm also a recovering anorexic and I'm still a little about weight gain being a side effect of medication. Hydrocodone can cause digestion problems that may discourage you from eating. The Johns Hopkins School of Medicine and Drugs.com report that opiates such as hydrocodone can cause constipation because they suppress you central nervous system. Does Hydrocodone Cause Weight Gain?? MAC9924 I am new here but am going on my second round of hydrocodone addition and I'm wondering if anyone else has had this same issue. Best Answer: Besides what ''Villie'' answered, which btw is a good answer, I agree with everything this user said. Hydrocodone can also cause food cravings, which of course will make you want to eat more.